Exposure to Hycanthone alters chromatin structure around specific gene functions and specific repeats in Schistosoma mansoni
Schistosoma mansoni is a parasitic plathyhelminth responsible for intestinal schistosomiasis (or bilharziasis), a disease affecting 67 million people worldwide and causing an important economic burden.The schistosomicides hycanthone, and its later proxy oxamniquine, were widely used for treatments in endemic areas during the 20th century.Recently,